bioRxivNeurosciencePreprint
Cytokine and Leukocyte Profiling Reveal Pro-Inflammatory and Autoimmune Features in Frontotemporal Dementia Patients
Philipp A. JaegeriD, Trisha M. Stan, Eva Czirr, Markus Britschgi, Daniela Berdnik, Ruo-Pan Huang, Bradley F. Boeve, Adam L. Boxer, NiCole Finch, Gabriela K. Fragiadakis, Neill R. Graff-Radford, Ruochun Huang, Hudson Johns, Anna Karydas, David S. Knopman, Michael Leipold, Holden Maecker, Zachary Miller, Ronald C. Petersen, Rosa Rademakers, Chung-Huan Sun, Steve Younkin, Bruce L. Miller, Tony Wyss-Coray
Abstract
The growing link between systemic environment and brain function opens the possibility that cellular communication and composition in blood are correlated with brain health. We tested this concept in frontotemporal dementia with novel, unbiased tools that measure hundreds of soluble signaling proteins or characterize the vast immune cell repertoire in blood. With these tools we discovered complementary abnormalities indicative of abnormal T cell populations and autoimmunity in frontotemporal dementia.
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.
William Richard Bevan-Jones, Thomas Cope, … James Benedict Rowe·BrainPeer-reviewed·Jan 27, 2020
- Immune-related genetic enrichment in frontotemporal dementia
Iris Broce, Celeste M M. Karch, … John Collinge·PLoS MedicinePeer-reviewed·Jan 9, 2018
- Early peripheral immune signaling precedes tau elevation and blood-brain barrier disruption in Alzheimer's disease
Aaron Burberry, Penelope H. Benchek, … Jagan A. Pillai·bioRxiv·Apr 4, 2026
- Dissecting the Human Leptomeninges at single-cell resolution
Nicola A. Kearns, Artemis Iatrou, … Yanling Wang·Nature CommunicationsPeer-reviewed·Nov 3, 2023
- Single-cell multimodal omics and directly reprogrammed neurons to probe reduced penetrance in Frontotemporal Dementia
Karthick Natarajan, Jesper Eisfeldt, … Caroline Graff·Acta Neuropathologica CommunicationsPeer-reviewed·Aug 3, 2021
- Early beta-amyloid accumulation in the brain is associated with peripheral T cell alterations
C. Gericke, T. Kirabali, … A. Gietl·bioRxiv·Jan 17, 2023