Nicola A. Kearns

This study creates a multi-omic atlas of the choroid plexus in Alzheimer's disease, identifying disease-associated cell state transitions and functional impairments.

The paper evaluates the AICS-0090 dCas9-KRAB iPSC line for modeling microglia-like cells and their responses to disease-relevant stimuli, finding stimulus-specific transcriptomic and functional responses.

The paper uses spatial transcriptomics to analyze Aβ plaques and glial interactions in AD brains, finding that low Aβ areas show more neuronal loss and high-glia areas show inflammation and neurodegeneration.

The paper identifies AD-associated lncRNAs with spatial and cell-type-specific expression patterns and shows OIP5-AS1 contributes to microglial activation in AD.

This study identifies YTHDF proteins as key regulators of Alzheimer's disease brain gene signatures through m6A-dependent and independent mechanisms.

This study provides the first single-nuclei profiling of human leptomeninges, identifying cell types and gene expression patterns linked to Alzheimer's disease.