Ganglioside GM1 produces stable, short, and cytotoxic Aβ40 protofibrils
Abstract
Monosialoganglioside GM1-bound amyloid {beta}-peptides have been found in patients brains exhibiting early pathological changes of Alzheimer s disease. Herein, we report the ability of non-micellar GM1 to modulate A{beta}40 aggregation resulting in the formation of stable, short, rod-like, and cytotoxic A{beta}40 protofibrils with the ability to potentiate both A{beta}40 and A{beta}42 aggregation.
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