M. I. Ivanova

Non-micellar ganglioside GM1 induces an instantaneous conformational change in Aβ42 leading to the modulation of the peptide amyloid-fibril pathway

This study shows non-micellar GM1 induces a conformational change in Aβ42, modulating its fibril formation pathway and exhibiting prion-like properties.

Ganglioside GM1 produces stable, short, and cytotoxic Aβ40 protofibrils

This study shows that GM1 stabilizes short, cytotoxic Aβ40 protofibrils and enhances aggregation of both Aβ40 and Aβ42.

Small Molecule Induced Toxic Human-IAPP Species Characterized by NMR

This study shows CurDAc inhibits hIAPP aggregation and disaggregates fibers, producing a toxic oligomer.

Mechanistic Insights into the Protective Roles of Polyphosphate Against Amyloid Cytotoxicity

This study investigates how polyphosphate (polyP) affects α-synuclein fibril formation and cytotoxicity, finding that polyP alters fibril morphology and reduces membrane interaction, suggesting potential therapeutic applications.