International Journal of Molecular SciencesGeneticsPeer-reviewed journal article
Regulation Network of Colorectal Cancer Specific Enhancers in Progression of Colorectal Cancer
Bohan CheniD, MA Yi-ping, Jinfang Bi, Wenbin WangiD, Anshun He, Guangsong SuiD, Zhongfang Zhao, Jiandang ShiiD, Lei ZhangiD
Abstract
Enhancers regulate multiple genes through higher-order chromatin structure and further affect cancer progression. Epigenetic changes in cancer cells activate several cancer specific enhancers that are silenced in normal cells. These cancer specific enhancers are potential therapeutic targets of cancer. However, functions and regulation network of colorectal cancer specific enhancers are still unknown. Here in this study, we profile colorectal cancer specific enhancers and reveal the regulation network of these enhancers by analysis of HiChIP, Hi-C and RNA-seq data. We propose the regulation network of colorectal cancer specific enhancers plays important role in progression of colorectal cancer.
- organism: human
- assay: Hi-C
- assay: ChIP-seq
- assay: bulk RNA-seq
- research focus: gene regulatory network inference
- approach: statistical model
- approach: experimental assay
- Citations
- 11
- FWCI
- 0.47
- Field percentile
- top 45%
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