Philip Law

The paper uses CRISPRi Perturb-seq to identify 238 enhancer-gene regulatory associations in colorectal cancer and integrates chromatin data to understand their spatial organization.

The paper identifies CCDC88C as a risk gene for ER-positive breast cancer by analyzing functional variants from GWAS signals using a massively parallel reporter assay.

This study identifies rs3087967 as the causal variant at 11q23.1 that increases colorectal cancer risk by dysregulating POU2AF2, a key activator of tuft cell transcription.

This study uses Mendelian randomisation to identify causal risk factors for eight cancers, finding both well-established and novel molecular factors.

This study improves polygenic risk scores for colorectal cancer by combining Asian and European ancestry data, enhancing risk prediction across diverse racial and ethnic groups.