Task Related Neural Activity Following Primary Motor Cortical Ischemic Injury in Rats

Abstract

Acquired injuries to primary motor cortex (M1) contribute to motor impairment and disability. Functional recovery is predicated on the reorganization of spared areas, which has been demonstrated through cortical motor map representations and neuroanatomical projection and termination patterns. The purpose of this study was to understand how neurophysiological outputs of spared motor areas relate to motor recovery of a skilled reach task following an ischemic infarct to M1. We examined changes in single unit activity within ipsilesional pre-motor (PM) and contralesional M1 cortices of rats during a behavioral task after a unilateral ischemic injury to ipsilesional M1. The data show a shift in neuronal firing patterns in the contralateral PM and ipsilateral M1 during behavioral recovery in lesion rats compared to a non-lesion control group, suggesting that spike-timing properties are altered in specific phases of the task, and that this altered activity may support spontaneous restoration of motor behavior. SIGNIFICANCE STATEMENTFollowing ischemic stroke to primary motor cortex (M1), motor recovery is associated with reorganization of spared cortical motor areas in injured and spared hemispheres. Currently, it is unclear how cortical plasticity within spared motor areas relates to motor recovery. This study examines how task-related neural activity within spared motor areas in rats correlates with motor restoration of a skilled reach task following an ischemic infarct to M1. The data suggest contralateral pre-motor and ipsilateral M1 alter their neural response profiles with respect to the timing of a motor task during recovery. To our knowledge, this is the first demonstration of a compensatory single-spike neurophysiological mechanism that may explain how remote, spared cortical areas contribute to functional recovery after M1 injury.