Randolph J. Nudo

This study evaluates a hydrogel-based approach for single-stage traumatic brain injury treatment in rats, showing improved motor function and reduced brain atrophy through controlled release of BMP-2.

This study compares cortical reorganization after motor cortex or internal capsule strokes in rats, finding delayed recovery and no long-term reorganization following internal capsule lesions.

This study identifies corticocortical connections of the rostral forelimb area in rats, showing similarities to primate ventral premotor cortex connections.

This study investigates post-ischemic connectivity between premotor and sensory cortex in rats following a primary motor cortex injury, finding evidence of crosstalk and functional recovery.

This paper introduces SEEC, a method using ICMS and multi-unit recordings to assess mesoscale effective connectivity in sensorimotor cortex of squirrel monkeys, showing stable short-latency responses correlated with anatomical connections.

This study shows that spike-triggered intraspinal microstimulation improves motor recovery in rats with spinal cord injury, as measured by BBB scores and Horizontal Ladder task performance.

This study compares activity-dependent stimulation (ADS) to random stimulation (RS) in rats, showing ADS modulates firing properties and promotes synaptogenesis in the somatosensory area.

This study examines how spinal cord injury affects neural activity and conduction time in rats, finding that short-latency responses persist while long-latency responses are disrupted.

This study shows that 4 weeks after primary motor cortex injury, there are significant neuroplastic changes in cortical connections, including increased boutons and altered fiber pathways between the ventral premotor cortex and somatosensory cortex.

This study investigates the effects of temporarily inactivating the motor cortex in rats to understand its role in mediating forelimb movement through the premotor cortex.

This study examines how task-related neural activity in spared motor areas of rats correlates with motor recovery after an ischemic injury to the primary motor cortex.

This study examines the long-term stability of task-related neural activity in healthy rats during reaching movements, showing consistent patterns in primary and premotor cortex over several weeks.

This study compares open-loop and closed-loop intracortical microstimulation in rats, finding that activity-dependent stimulation more effectively increases short-latency evoked spikes in distant cortical areas.

This study shows that axotomy leads to dendritic spine loss and presynaptic hyper-excitability in injured neurons, which can be normalized by exogenous netrin-1.