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bioRxivDevelopmental BiologyPreprint

Pre-existent adult sox10+ cardiomyocytes contribute to myocardial regeneration in the zebrafish

Marcos Sande-MelóniD, Ines Joao MarquesiD, María Galardi‐CastillaiD, Xavier LangaiD, María Pérez-López, Marius Alexandru BotosiD, Gabriela GuzmániD, David Miguel Ferreira FranciscoiD, Dinko PavlinićiD, Vladimı́r BenešiD, Rémy BruggmanniD, Nadia MercaderiD

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Abstract

During heart regeneration in the zebrafish, fibrotic tissue is replaced by newly formed cardiomyocytes derived from pre-existing ones. It is unclear whether the heart is comprised of several cardiomyocyte populations bearing different capacity to replace lost myocardium. Here, using sox10 genetic fate mapping, we identified a subset of pre-existent cardiomyocytes in the adult zebrafish heart with a distinct gene expression profile that expanded massively after cryoinjury. Genetic ablation of sox10+ cardiomyocytes severely impaired cardiac regeneration revealing that they play a crucial role for heart regeneration.

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