Jan Philipp Junker

This study shows that pre-existing chromatin accessibility in δ-cells enables their conversion into hybrid cells after β-cell loss in zebrafish, facilitating endocrine plasticity.

This study shows lineage history and developmental context jointly shape tumor-state architecture in MYCN-driven zebrafish neuroblastoma.

The paper introduces moslin, a method that combines lineage and gene expression data across time points to predict cell fate and decision driver genes.

This study identifies transcription factors that induce vascular blood stem cell niches in vivo, enabling synthetic niche generation and potential therapeutic applications.

The paper identifies fibroblast-like cell types as key drivers of heart regeneration in zebrafish using single-cell transcriptomics and lineage tracing.

This study maps β-cell regeneration in zebrafish using single-cell transcriptomics, identifying hybrid β/δ cells as key contributors to diabetes recovery.

The paper uses spatial transcriptomics and single-cell RNA labeling to study mRNA localization and dynamics in early zebrafish embryos, revealing transport to primordial germ cells and evolutionary conservation.

The paper quantifies embryo-to-embryo variability in zebrafish endoderm cell numbers, showing that stochastic variation in a sub-population leads to laterality defects.

The paper reveals that cells move in a circular trajectory in transcriptome space during the cell cycle, minimizing transcriptional changes.

This study shows morphine reduces pain after heart cryoinjury in zebrafish without hindering regeneration, while lidocaine delays repair.

The paper uses sci-ATAC-seq and a new tool, ScregSeg, to analyze chromatin dynamics in zebrafish embryos, revealing roles of npas4l/cloche in cell and regulatory states.

The paper uses spatial transcriptomics to identify novel fertility genes in C. elegans by analyzing gene expression patterns in males and hermaphrodites.

The paper introduces a method to trace cell lineages and profile transcriptomes in thousands of single cells using CRISPR/Cas9 and scRNA-seq in zebrafish.

scartrace uses Cas9-induced genetic scars for clonal analysis in zebrafish, aiming at lineage reconstruction across many cells at once rather than the small subsets imaging covers.