bioRxivMicrobiology
Development of a nucleoside-modified mRNA vaccine against clade 2.3.4.4b H5 highly pathogenic avian influenza virus
C. Furey, N. Ye, L. Kercher, J. DeBeauchamp, J. C. Crumpton, T. Jeevan, C. Patton, J. Franks, M.-G. Alameh, S. H. Y. Fan, A. T. Phan, C. A. Hunter, R. J. Webby, D. Weissman, S. E. Hensley
Abstract
Highly pathogenic avian influenza viruses from H5 clade 2.3.4.4b are circulating at unprecedently high levels in wild and domestic birds and have the potential to adapt to humans. We generated an mRNA lipid nanoparticle (LNP) vaccine encoding the hemagglutinin (HA) glycoprotein from a clade 2.3.4.4b H5 isolate. We show that the vaccine is immunogenic in mice and ferrets and prevents morbidity and mortality of ferrets following 2.3.4.4b H5N1 challenge.
- organism: mouse
- organism: rat
- organism: non-human primate
- assay: multiome
- research focus: drug response / drug discovery
- approach: experimental assay
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