Scott E. Hensley

This study evaluates an H5 mRNA-LNP vaccine in lactating dairy cows, finding it reduces viral replication and disease in mammary glands.

This study shows that postpartum lactation enhances maternal antiviral immunity, improving survival and disease outcomes after influenza infection.

This paper develops a multivalent mRNA-LNP vaccine with eight swine IAV HA antigens, showing broad neutralizing antibodies and protection against viral challenge.

This study evaluates the immune response of an H5 mRNA-LNP vaccine in calves against H5N1 influenza, showing robust antibody and CD8+ T cell responses and protection against infection.

This study reports neutralization titers from 355 human sera against 148 influenza strains, showing reduced neutralization of new H3N2 and H1N1 variants.

This study shows Notch2 signaling enhances TLR3 and TLR4 responsiveness in MZ B cells, promoting immune responses to viral and bacterial pathogens.

This study shows H5N1 clade 2.3.4.4b viruses bind human MHC-II HLA-DR for cell entry, independent of sialic acid, and identifies host genetic and antibody factors that modulate this interaction.

The paper measures seroprevalence of H5N1 and SARS-CoV-2 antibodies in owned and feral cats in Philadelphia, finding rare H5N1 exposure but common SARS-CoV-2 exposure.

This study compares neutralizing antibody titers from egg-derived and recombinant protein influenza vaccines against diverse H1N1 strains, finding that egg-derived vaccines induce less boost against a new clade with specific antigenic mutations.

This study tracks CD4+ T cell memory development after three mRNA vaccinations in SARS-CoV-2-naive individuals, showing primary vaccination drives memory pool size and boosters refine its quality and breadth.

The study assesses the pandemic risk of a fatal zoonotic H3N8 influenza virus from chickens, finding it has moderate pandemic potential due to its ability to infect humans and replicate in human cells.

A sequencing-based neutralization assay across 78 H3N2 HA strains and 150 sera shows strain growth in 2023 tracks the fraction of sera with low titers, but not pooled-serum titers.

Sequencing-based neutralization of 91 H3N2 and H1N1 hemagglutinins against 302 human sera (27,409 titers) shows reduced titers to H3N2 subclade K and H1N1 D.3.1.1.

The paper investigates H5N1 transmission on dairy farms by sampling air, wastewater, and milk, finding infectious virus in air and wastewater, viral RNA in cow breath, and subclinical infections in cows.

This study shows that adding IL-12 mRNA-LNPs to an mRNA vaccine enhances CD8+ T cell responses against model antigens and improves protection against infections and tumors.

This study uses deep mutational scanning to analyze H5 hemagglutinin mutations and their impact on pandemic risk factors in influenza viruses.

This study shows that pre-existing antibodies inhibit de novo B cell responses to influenza antigens in mice, but not to other vaccine antigens.

This study shows that clade 2.3.4.4b H5N1 influenza viruses bind efficiently to avian-type sialic acid receptors but not human-type receptors.