M.-G. Alameh

This paper identifies translation inhibitors that enable ex vivo expansion of human hematopoietic stem cells from umbilical cord blood while maintaining their function and enabling gene editing.

This paper develops VCAM-targeted lipid nanoparticles to enhance drug delivery to the blood-brain barrier in acute ischemic stroke, reducing infarct volume and mortality.

This study develops an mRNA vaccine against clade 2.3.4.4b H5 avian influenza virus and shows it is immunogenic and protective in mice and ferrets.

This study shows the microbiome affects nucleic acid vaccine responses differently depending on the vaccine type, enhancing mRNA-LNP responses but suppressing DNA-prime/DNA-protein-boost responses.

This study develops lipid nanoparticles (LNPs) that efficiently deliver mRNA to the placenta in vivo without toxicity, showing potential for treating placental dysfunction.

This study investigates whether mRNA-based SARS-CoV-2 vaccines induce interferon responses in individuals with Aicardi Goutieres Syndrome (AGS) and finds no significant increase in interferon signatures.

This study uses mRNA lipid nanoparticles to deliver an active STING mutant to treat STING-deficient cancers, enhancing immune response and inducing cancer cell death.

This study shows that combining mRNA vaccines targeting the SARS-CoV-2 spike and nucleoprotein proteins enhances protection against the delta variant in animal models.