Nature CommunicationsMicrobiologyPeer-reviewed journal article
Prevalent chromosome fusion in Vibrio cholerae O1
Aline CuénodiD, Denise ChaciD, Ashraful Islam KhaniD, Fahima ChowdhuryiD, Randy W. Hyppa, Susan M. MarkiewicziD, Amelia Rice, Akhil KholwadwalaiD, Stephen B. CalderwoodiD, Edward Thomas RyaniD, Jason B. HarrisiD, Regina C. LaRocqueiD, Taufiqur Rahman BhuiyaniD, Gerald R. SmithiD, Firdausi QadriiD, Patrick LypaczewskiiD, Ana A. WeiliD, B. Jesse ShapiroiD
Abstract
Two circular chromosomes are a defining feature of the family Vibrionaceae, including the pathogen Vibrio cholerae, with rare reports of isolates with a single, fused chromosome. Here we report chromosome fusions in clinical V. cholerae O1 isolates, including several independent fusion events stable enough to be transmitted between patients within a household. Fusion occurs in a 12 kilobase-pair homologous sequence shared between the two chromosomes, which may lead to reversible chromosomal fusion.
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