Patrick Lypaczewski

This study screens Arctic bacteria to discover antibacterial compounds, identifying koreenceine A from a Pseudomonas isolate and confirming its antibiotic activity through genetic analysis.

This paper demonstrates a method to sequence bacteriophage genomes directly from single plaques without DNA extraction, achieving high ANI scores compared to traditional methods.

The paper identifies a microbiota-dependent type 3 immune response in mice during weaning that involves γδ T cells, which limit C. difficile growth and maintain intestinal barrier integrity.

The paper introduces DBCO-modified PCR primers for enzyme-free click chemistry ligation in nanopore amplicon sequencing, achieving higher pore occupation and reads than commercial solutions.

This study shows nutrient enrichment reduces bacterioplankton taxonomic diversity but connectivity can restore functional diversity in highly stressed freshwater communities.

The paper investigates the relationship between co-occurrence and horizontal gene transfer (HGT) in marine bacteria, finding a significant association independent of phylogeny.

This study sequenced V. cholerae genomes from Bangladesh in 2018, revealing geographic variation in lineage dominance and pangenome diversity across regions.

The paper reports chromosome fusions in clinical V. cholerae O1 isolates, showing stable transmission between patients within a household.

This study compares genetic diversity of Vibrio cholerae O1 in vomit and stool from cholera patients, finding reduced diversity in stool and some gene loss between samples.