ScienceMicrobiologyPeer-reviewed journal article
Emergence and interstate spread of highly pathogenic avian influenza A(H5N1) in dairy cattle
Thao-Quyen NguyeniD, Carl R. HutteriD, Alexey MarkiniD, Megan N. ThomasiD, Kristina LantziD, Mary Lea KillianiD, Garrett M. JanzeniD, Sriram VijendraniD, Sanket WagleiD, Blake InderskiiD, Drew Robert Magstadt, Ganwu LiiD, Diego G. DieliD, Elisha FryeiD, Kiril M. DimitroviD, Amy K. SwinfordiD, Alexis C. ThompsoniD, Kevin R. SnekvikiD, David L. SuareziD, Erica SpackmaniD, Stacey SchwabenlanderiD, Sara C. Ahola, Kammy R. Johnson, Amy L. Vincent BakeriD, Suelee Robbe‐AustermaniD, , Tavis K. AndersoniD
Abstract
Highly pathogenic avian influenza (HPAI) viruses cross species barriers and have the potential to cause pandemics. In North America, HPAI A(H5N1) viruses related to the goose/Guangdong 2.3.4.4b hemagglutinin phylogenetic clade have infected wild birds, poultry, and mammals. Our genomic analysis and epidemiological investigation showed that a reassortment event in wild bird populations preceded a single wild bird-to-cattle transmission episode. The movement of asymptomatic cattle has likely played a role in the spread of HPAI within the United States dairy herd. Some molecular markers in virus populations were detected at low frequency that may lead to changes in transmission efficiency and phenotype after evolution in dairy cattle. Continued transmission of H5N1 HPAI within dairy cattle increases the risk for infection and subsequent spread of the virus to human populations.
- organism: multiple species
- research focus: host-pathogen & immune response
- approach: experimental assay
- Citations
- 262
- FWCI
- 127.57
- Field percentile
- top 1%
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