The ORF6 accessory protein contributes to SARS-CoV-2 virulence and pathogenicity in the naturally susceptible feline model of infection
Mohammed Nooruzzaman, Salman Latif Butt, Ruchi Rani, C.H. Ye, Andrew D. Miller, Luis Martínez‐Sobrido, Yīng Fāng, Diego G. Diel
This study shows that deleting ORF6 from SARS-CoV-2 reduces virulence and pathogenicity in cats, with decreased immune suppression and reduced viral replication.
Journal of Virology · Feb 27, 2026Peer-reviewedMicrobiology