Protein ScienceBioinformaticsPeer-reviewed journal article
Intrinsic Protein Disorder, Conditional Folding and AlphaFold2
Damiano PiovesaniD, Alexander Miguel MonzóniD, Silvio C. E. TosattoiD
Abstract
Intrinsically disordered regions (IDRs) defying the traditional protein structure-function paradigm have been difficult to analyze. AlphaFolds recent breakthrough in predicting protein structures accurately offers a fresh perspective on IDR prediction as assessed on the CAID dataset. Surprisingly, AlphaFold is highly competitive for predicting both IDRs and conditionally folded regions, demonstrating the plasticity of the disorder to structure continuum.
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