EMHP: An accurate automated hole masking algorithm for single-particle cryo-EM image processing

Abstract

1. Introduction 1. Introduction 2. Software Package Overview 3. Conclusions Funding References The recent surge in popularity of single-particle cryo-EM as a tool for molecular structure determination alongside advances in software that have reduced the computational infrastructure needed to process single-particle datasets (Kimanius et al, 2016) have created the need for a more streamlined suite of tools to locally facilitate initial data treatment and make processing more attainable at the workstation level.\n\nCurrent technical limitations inherent to the process of structure determination via single-particle cryo-EM require collecting very large data sets - often several thousands of images. This task is facilitated by automated imaging software, however downstream preprocessing steps such as quality asses ...