Author

S. H. W. Scheres

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 6 Approach:experimental assay· 5 Research Focus:protein structure prediction· 5 Approach:microscopy & imaging analysis· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:deep learning· 2 Assay:electronic health records· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

D. Kimanius· 4 shared T. Nakane· 4 shared A. G. Murzin· 2 shared E. Lindahl· 2 shared J. A. G. Briggs· 2 shared J. Zivanov· 2 shared K. Qu· 2 shared M. Goedert· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersBiophysics

D. Kimanius

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Disease-specific tau filaments assemble via polymorphic intermediates

S. Lövestam, D. Li, J. L. Wagstaff, A. Kotecha, D. Kimanius, S. H. McLaughlin, A. G. Murzin, S. M. V. Freund, M. Goedert, S. H. W. Scheres

This study uses cryo-EM to analyze intermediate structures in tau filament assembly, revealing shared and condition-dependent intermediates in Alzheimer's and CTE pathogenesis.

bioRxiv · Jul 24, 2023Biophysics

Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere

T. Dendooven, Z. Zhang, J. Yang, S. H. McLaughlin, J. Schwab, S. H. W. Scheres, S. Yatskevich, D. Barford

The paper determines the cryo-EM structure of the complete inner kinetochore of budding yeast, revealing its architecture and DNA interactions.

bioRxiv · Dec 12, 2022Biochemistry

New tools for automated cryo-EM single-particle analysis in RELION-4.0

D. Kimanius, L. Dong, G. Sharov, T. Nakane, S. H. W. Scheres

The paper introduces new tools in RELION-4.0 for automated cryo-EM single-particle analysis, including a gradient descent algorithm, a neural network for 2D class selection, and a job framework with metadata linking.

bioRxiv · Sep 30, 2021Biophysics

Structures, conformations and distributions of SARS-CoV-2 spike protein trimers on intact virions

Z. Ke, J. Oton, K. Qu, M. Cortese, V. Zila, L. McKeane, T. Nakane, J. Zivanov, C. J. Neufeldt, J. M. Lu, J. Peukes, X. Xiong, H.-G. Krausslich, S. H. W. Scheres, R. Bartenschlager, J. A. G. Briggs

This study uses cryo-electron microscopy to determine the structure, conformational flexibility, and distribution of SARS-CoV-2 spike protein trimers on intact virions.

bioRxiv · Jun 27, 2020Microbiology

A thermostable, closed, SARS-CoV-2 spike protein trimer.

X. Xiong, K. Qu, K. A. Ciazynska, M. Hosmillo, A. P. Carter, S. Ebrahimi, Z. Ke, S. H. W. Scheres, L. Bergamaschi, G. L. Grice, Y. Zhang, The CITIID-NIHR COVID-19 BioResource Collaboration, J. A. Nathan, S. Baker, L. C. James, , J. A. G. Briggs

This paper designs a thermostable, closed SARS-CoV-2 spike protein trimer that remains in the pre-fusion state and can be used in serological assays.

bioRxiv · Jun 15, 2020Biochemistry

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

W. Zhang, B. Falcon, A. G. Murzin, J. Fan, R. A. Crowther, M. Goedert, S. H. W. Scheres

This study characterizes heparin-induced tau filaments using cryo-EM and immuno-EM, revealing structural diversity and differences from Alzheimer’s and Pick’s disease filaments.

bioRxiv · Nov 13, 2018Biophysics

RELION-3: new tools for automated high-resolution cryo-EM structure determination

J. Zivanov, T. Nakane, B. Forsberg, D. Kimanius, W. J. H. Hagen, E. Lindahl, S. H. W. Scheres

RELION-3 introduces new tools for automated high-resolution cryo-EM structure determination, improving resolution through enhanced processing methods and hardware flexibility.

bioRxiv · Sep 19, 2018Biophysics

Characterisation of molecular motions in cryo-EM single-particle data by multi-body refinement in RELION

T. Nakane, D. Kimanius, E. Lindahl, S. H. W. Scheres

The paper introduces a new cryo-EM single-particle analysis tool called multi-body refinement to model flexible macromolecular complexes and generate reconstructions and motion movies.

bioRxiv · Mar 22, 2018Biophysics