bioRxivMicrobiologyPreprint
Survival mechanism of a novel marine multistress-tolerant Meyerozyma guilliermondii GXDK6 under high NaCl stress as revealed by integrative omics analysis
C. Jiang, X. Cai, H. Sun, H. Bai, Y. Chen, M. Kashif, R. Bu, X. Mo, G. Su, Q. Ou, B. Yan
Abstract
A novel strain named Meyerozyma guilliermondii GXDK6 was provided in this work, which was confirmed to survive independently under high salt stress (12% NaCl) or co-stress condition of strong acid (pH 3.0) and high salts (10% NaCl) without sterilization. Its survival mechanism under high salt stress was revealed by integrated omics for the first time. Whole-genome analysis showed that 14 genes (e.g., GPD1 and FPS1) of GXDK6 relevant to salt tolerance were annotated and known to belong to various salt-resistant mechanisms (e.g., regulation of cell signal transduction and glycerol metabolism controls). Transcriptome sequencing results indicated that 1220 genes (accounting for 10.15%) of GXDK6 were differentially transcribed (p View larger version (36K): org.highwire.dtl.DTLVardef@928135org.highwire.dtl.DTLVardef@60c713org.highwire.dtl.DTLVardef@1adb19dorg.highwire.dtl.DTLVardef@67caaa_HPS_FORMAT_FIGEXP M_FIG C_FIG
- organism: yeast
- assay: whole-genome sequencing
- assay: bulk RNA-seq
- research focus: gene regulatory network inference
- research focus: differential expression
- approach: statistical model
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