S. Srivastava

Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution

This study integrates spatial transcriptomics and single-cell data from gastric cancer samples to reveal tumor ecosystem dynamics, evolutionary trajectories, and immune microenvironment features.

Radiation resistance in cervical cancer: An insight on mitochondrial associated membranes and its related proteins.

This study investigates radiation resistance in cervical cancer by analyzing mitochondrial-associated membrane (MAM) alterations and identifies BNIP3L as a potential target for improving radiation therapy efficacy.

Spatially resolved niche and tumor microenvironmental alterations in gastric cancer peritoneal metastases

This study identifies transcriptomic and immune features of gastric cancer peritoneal metastases, highlighting predictive markers and therapeutic targets in the tumor microenvironment.

Integrated electrophysiological and genomic profiles of single cells reveal spiking tumor cells in human glioma

The paper identifies hybrid cells in human glioma with both neuronal and glial electrophysiological and transcriptomic features using Patch-sequencing and a new computational tool.

Proteomic analysis of gut in Labeo rohita reveals ECM as Key Player in host's Response to Aeromonas hydrophila Infection

This study identifies ECM proteins as key players in Labeo rohita's immune response to Aeromonas hydrophila infection through proteomic analysis of gut tissue.

Spatial interactions modulate tumor growth and immune infiltration

This study uses computational modeling to explore how spatial interactions between immune cells and collagen fibers influence tumor growth and immune infiltration.

Development and clinical validation of molecular subgrouping in medulloblastoma by targeted methylation sequencing

This paper develops and validates a targeted methylation sequencing method using Sanger sequencing for medulloblastoma classification, achieving accurate subgrouping without requiring NGS infrastructure.

Targeting endothelial FOXO1 protects diabetic β-cells and improves wound healing

This study shows that targeting endothelial FOXO1 reduces IGF2 levels, improves β-cell function, and enhances wound healing in diabetes.

AAO2 impairment improves aldehyde detoxification by AAO3 in Arabidopsis leaves exposed to UVC or Rose Bengal.

This study shows that AAO2 deficiency enhances AAO3 aldehyde detoxification in Arabidopsis, improving stress resistance.

Enhancing CAR T cell therapy using Fab-Based Constitutively Heterodimeric Cytokine Receptors

This paper introduces a dimerization domain from IgG1 antibodies to create engineered cytokine receptors that mimic natural heterodimerization, enhancing CAR T cell therapy efficacy.

Identification of potential molecular mimicry in pathogen-host interactions

The paper identifies molecular mimicry between humans and 32 pathogens using bioinformatics, finding 1878 mimicked regions in human proteins and highlighting their functional relevance.

Investigating miRNA signatures in metastatic breast cancer: An in silico analysis.

This study identifies differentially expressed miRNAs in breast cancer and their target genes, suggesting potential therapeutic targets.

A novel biomechanical indicator for impaired ankle dorsiflexion function during walking in individuals with chronic stroke

This study identifies ankle angular velocity and acceleration as reliable indicators of impaired dorsiflexion function in post-stroke gait, outperforming traditional measures like foot clearance.

Exploration of T-cell immune responses by expression of a dominant-negative SHP1 and SHP2

This study investigates the role of SHP1 and SHP2 in T-cell immunosuppression by expressing truncated variants and shows that dSHP2 can alleviate PD1-mediated suppression in CAR T cells.

Spatiotemporal Genomic Profiling of Intestinal Metaplasia Reveals Clonal Dynamics of Gastric Cancer Progression

This study analyzes genomic and transcriptomic data from gastric samples to identify driver genes and clonal dynamics in intestinal metaplasia, showing their progression to gastric cancer and the role of microbial dysbiosis.

PERK arm of UPR selectively regulates ferroptosis in colon cancer cells by modulating the expression of SLC7A11 (System Xc-)

This study shows that PERK inhibition reduces SLC7A11 expression and sensitizes colon cancer cells to ferroptosis, suggesting PERK inhibitors as potential therapeutics.

Wat1/mLst8, a TOR complex protein regulates mitochondrial integrity and calcium ion homeostasis in fission yeast S. pombe

This study shows Wat1/mLst8 regulates mitochondrial integrity, calcium homeostasis, and respiratory function in fission yeast through interactions with TORC1 and mitochondrial proteins.

Metaproteomic analysis of nasopharyngeal swab samples to identify microbial peptides and potential co-infection status in COVID-19 patients

This study uses metaproteomic analysis of nasopharyngeal swabs to identify microbial peptides and co-infections in COVID-19 patients, revealing potential pathogens and upregulated species in severe cases.

AP2XII-2 coordinates transcriptional repression for Toxoplasma gondii sexual commitment

This study identifies AP2XII-2 as a transcription factor that represses specific genes involved in Toxoplasma gondii sexual development, including AP2X-10 and AAH1.

Novel Multi-Epitope Vaccine candidate derived from critically important proteins of Monkeypox isolates

This paper identifies and designs multi-epitope vaccine candidates from monkeypox virus proteins using in silico methods, finding highly conserved and immunogenic epitopes suitable for vaccine development.

Novel 'GaEl antigenic patches' identified by 'reverse epitomics' approach to design multi-patch vaccines against NIPAH infection, a silent threat to global human health

This paper identifies novel antigenic patches using reverse epitomics to design multi-patch vaccines against Nipah virus, showing broad population coverage and stable molecular interactions.

Asparagine starvation suppresses histone demethylation through iron depletion

This study shows asparagine starvation reduces histone demethylation by depleting labile iron, which is essential for JHDMs function, and this effect is mediated through IREB2 and TFRC regulation.

Targeting Epsins by nanotherapy regulates lipid metabolism and promotes ABCG1-mediated cholesterol efflux to fortify atheroma regression

This study shows that targeting Epsins in macrophages with nanotherapy reduces lipid uptake and increases cholesterol efflux, promoting atheroma regression.

Pink1-mediated mitophagy in the endothelium releases proteins encoded by mitochondrial DNA and activates neutrophil responses

This study identifies endothelial mitophagy as a source of mitochondrial formyl proteins that activate neutrophils and contribute to lung inflammation.

Collective invasion of the basement membrane in breast cancer driven by forces from cell volume expansion and local contractility

This study shows breast cancer cells invade the basement membrane using both proteases and mechanical forces from cell volume expansion and local contractility.

Structural bases for blockade and activation of BK channels by Ba2+ ions

The paper presents Cryo-EM structures of BK channels with Ba2+ ions, showing Ba2+ blocks the channel by occupying the selectivity filter and also binds to Ca2+ sites, with intermediate configurations observed.

Cell-to-cell variability of dynamic CXCL12-CXCR4 signaling and morphological processes in chemotaxis

The paper analyzes single-cell chemotaxis in breast cancer cells using CXCL12-CXCR4 signaling, identifying dynamic signaling oscillations and morphological changes as key factors in successful migration.

MHC-II molecules present RhoC-derived peptides on the surface of tumour cells

This study shows that RhoC peptides are presented on tumour cell surfaces via MHC-II, suggesting a new antigen presentation pathway relevant to cancer immunotherapy.

Novel tuberculosis combination regimens of two and three-months therapy duration

The paper predicts four pan-tuberculosis regimens that could cure tuberculosis in 2-3 months using mathematical modeling and pharmacokinetics/pharmacodynamic analysis of drug combinations.

Cyclic constrained immunoreactive peptides from crucial P. falciparum proteins: potential implications in malaria diagnostics

The paper identifies three cyclic constrained peptides from P. falciparum proteins that show immunoreactivity and diagnostic potential in field-collected samples.