Stephan Klähn

Multilevel engineering of cyanobacterial energy metabolism advances photosynthetic hydrogen production while revealing its constraints

This study enhances cyanobacterial photosynthetic hydrogen production by addressing multiple metabolic constraints, achieving higher yields but also revealing trade-offs with metabolic stability.

Conversion of CO2 into valuable products: Engineering the PirC-PGAM switch in cyanobacteria to direct carbon flux into desired products

This paper engineers the PirC-PGAM switch in cyanobacteria to redirect carbon flux toward desired products like sucrose and succinate, demonstrating a tunable control point for metabolic engineering.

The small protein SbtC is a functional component of the CO2 concentrating mechanism of cyanobacteria

The paper identifies SbtC as a small protein involved in the cyanobacterial CO2 concentrating mechanism, showing it forms a trimeric complex with SbtA and SbtB to regulate bicarbonate exchange.

When a chaotropic agent turns into a nutrient: Deciphering the assimilation of guanidine and its utilization to drive synthetic processes in cyanobacteria

This paper shows cyanobacteria can use guanidine as a nitrogen source, regulated by NtcA and a riboswitch, enabling precise gene control for synthetic biology.

Integrative analysis of the salt stress response in cyanobacteria

This study integrates transcriptomic, proteomic, and metabolomic data from Synechocystis sp. PCC 6803 to characterize the salt stress response, identifying key regulatory elements and metabolic changes.