Nature MethodsGenomicsPeer-reviewed journal article
GeNets: A unified web platform for network-based analyses of genomic data
Taibo LiiD, April KimiD, Joseph RosenbluhiD, Heiko HorniD, Liraz Greenfeld, David An, Andrew R. Zimmer, Arthur Liberzon, Jon Bistline, Ted Natoli, Yang Li, Aviad TsherniakiD, Rajiv Narayan, Aravind SubramanianiD, Ted LiefeldiD, Bang Wong, Dawn Anne ThompsoniD, Sarah E. CalvoiD, Steven A. CarriD, Jesse S. BoehmiD, Jacob D. JaffeiD, Jill P. MesiroviD, Nir HacoheniD, Aviv RegeviD, Kasper LageiD
Abstract
Functional genomics networks are widely used to identify unexpected pathway relationships in large genomic datasets. However, it is challenging to quantitatively compare the signal-to-noise ratio of different networks, the biology they describe, and to identify the optimal network to interpret a particular genetic dataset. Via GeNets users can train a machine-learning model (Quack) to make such comparisons; and they can execute, store, and share analyses of genetic and RNA sequencing datasets.
- assay: bulk RNA-seq
- research focus: benchmarking
- research focus: software / tool
- approach: machine learning (classical)
- Citations
- 55
- FWCI
- 3.56
- Field percentile
- top 5%
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