VGLUT2 functions as a differential marker for hippocampal output neurons

Christian Wozny; Prateep Sanker Beed; Noam Nitzan; Yona Pössnecker; Benjamin R. Rost; Dietmar Schmitz

doi:10.3389/fncel.2018.00337

NeuroscienceFrontiers in Cellular NeuroscienceOct 2, 2018

Peer-reviewed journal article

VGLUT2 functions as a differential marker for hippocampal output neurons

Christian Wozny iD, Prateep Sanker Beed iD, Noam Nitzan iD, Yona Pössnecker iD, Benjamin R. Rost iD, Dietmar Schmitz iD

Abstract

The subiculum is the gatekeeper between the hippocampus and cortical areas. Yet, the lack of a pyramidal cell-specific marker gene has made the analysis of the subicular area very difficult. Here we report that the vesicular-glutamate transporter 2 (VGLUT2) functions as a specific marker gene for subicular burst-firing neurons, and demonstrate that VGLUT2-Cre mice allow for Channelrhodopsin-2 (ChR2)-assisted connectivity analysis.

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