bioRxivCell Biology
Molecular mapping of transmembrane mechanotransduction through the β1 integrin-CD98hc-TRPV4 axis
R. Potla, M. Mariko Hirano-Kobayashi, H. Wu, H. Chen, A. Mammoto, B. D. Matthews, D. E. Ingber
Abstract
One of the most rapid (\nView larger version (44K):\norg.highwire.dtl.DTLVardef@11bfb51org.highwire.dtl.DTLVardef@10bcdaorg.highwire.dtl.DTLVardef@debf89org.highwire.dtl.DTLVardef@1f0bee5_HPS_FORMAT_FIGEXP M_FIG Graphical abstract\n\nC_FIG SUMMARYA direct path of mechanical signal transfer between {beta}1 integrin, CD98hc, and TRPV4 channels is identified that mediates ultra-rapid transmembrane mechanochemical conversion within focal adhesions.
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