Jinghui Jiang

The paper identifies a mutation in PIEZO1 that abolishes mechanical activation but not chemical activation, showing a direct link between mechanosensitivity and fetal hydrops.

This study defines the structural states and curvature-based activation/inactivation mechanisms of PIEZO1 using a mutant and molecular dynamics simulations.

This paper identifies how Piezo1 channels are tethered to the actin cytoskeleton via the E-cadherin-β-catenin complex, enabling mechanogating through direct force transmission.