Scientific ReportsBiochemistryPeer-reviewed journal article
Vps4 substrate binding and coupled mechanisms of Vps4p substrate recruitment and release from autoinhibition
Henry WienkersiD, Han HaniD, Frank G. WhitbyiD, Christopher P. HilliD
Abstract
The ESCRT pathways AAA+ ATPase, Vps4p, remodels ESCRT-III complexes to drive membrane fission. Here, we use peptide binding assays to further the understanding of substrate specificity and the mechanism of autoinhibition. Our results reveal unexpected sequence preference to the substrate binding groove and an elegant mechanism of regulation that couples localization to substrate with release from autoinhibition.
- Citations
- 2
- FWCI
- 0.63
- Field percentile
- top 39%
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