RNA Polymerase II is involved in 18S and 25S ribosomal RNA transcription, in Candida albicans

Introduction Introduction Results Discussion Methods Reference While in eukaryotes three RNA polymerases are involved in ribosome production [1] under usual growth conditions, the 18S and 25S ribosomal RNA (rRNA) components are thought to be exclusively the products of transcription by RNA polymerase I (Pol I) followed by processing [2]. We have observed recently, in Candida albicans during nutritional depletion and with TOR inhibition, the appearance of 18S and 25S rRNA molecules, resisting digestion by a 5'-phosphate-dependent exonuclease, indicating that they were different from the usual processed rRNA transcripts [3]. Candida albicans, a eukaryotic yeast, is a major cause of invasive fungal disease especially in immune compromised patients [4]. ...