DECONbench: a benchmarking platform dedicated to deconvolution methods for tumor heterogeneity quantification

Clémentine Decamps; A Arnaud; Florent Petitprez; Mira Ayadi; Aurélia Baurès; Lucile Armenoult; Nicolas Alcala; Francisco Avila Cobos; Luciana Batista; Anne-Françoise Batto; Yuna Blum; Florent Chuffart; Jerome F. Cros; L. Dirian; Daria Doncevic; Ghislain Durif; S. Y. Bahena Hernandez; Milan Jakobi; Rémy Jardillier; M. Jeanmougin; Paulina Jedynak; Basile Jumentier; Aliaksandra Kakoichankava; Maria Kondili; Jingwen Liu; Tiago Maié; J. Marécaille; Jane Merlevede; Maxime Meylan; Petr V. Nazarov

doi:10.1186/s12859-021-04381-4

BioinformaticsBMC BioinformaticsOct 2, 2021

Peer-reviewed journal article

DECONbench: a benchmarking platform dedicated to deconvolution methods for tumor heterogeneity quantification

Clémentine Decamps iD, A Arnaud iD, Florent Petitprez iD, Mira Ayadi iD, Aurélia Baurès, Lucile Armenoult, Nicolas Alcala iD, Francisco Avila Cobos iD, Luciana Batista, Anne-Françoise Batto iD, Yuna Blum iD, Florent Chuffart iD, Jerome F. Cros iD, L. Dirian, Daria Doncevic iD, Ghislain Durif iD, S. Y. Bahena Hernandez iD, Milan Jakobi, Rémy Jardillier, M. Jeanmougin, Paulina Jedynak iD, Basile Jumentier, Aliaksandra Kakoichankava iD, Maria Kondili iD, Jingwen Liu iD, , Magali Richard iD

Abstract

MotivationQuantification of tumor heterogeneity is essential to better understand cancer progressionand to adapt therapeutic treatments to patient specificities. ResultsWe present DECONbench, a web-based application to benchmark computational methods dedicated to quantify of cell-type heterogeneity in cancer. DECONbench includes benchmark datasets, computational methods and performance evaluation. It allows submission of new methods. Availability and implementationDECONbench is hosted on the open source codalab competition platform. It is freely available at: https://competitions.codalab.org/competitions/23660. Supplementary informationAdditional information is available online and on our website: https://cancer-heterogeneity.github.io/deconbench.html.

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