Author

S. J. Gosline

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:benchmarking· 2 Research Focus:cell type annotation· 2 Research Focus:database / resource· 2 Assay:proteomics· 2

Frequent Co-Authors

C. A. Pratilas· 3 shared K. Pollard· 3 shared A. C. Hirbe· 2 shared D. A. Largaespada· 2 shared D. K. Wood· 2 shared E. Conniff· 2 shared J. C. Pino· 2 shared J. Guinney· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

C. A. Pratilas

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Author profile →

5 papers

Recent·Most cited

CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon restoration of RB function in malignant peripheral nerve sheath tumors

J. Wang, A. Calizo, L. Zhang, J. C. Pino, Y. Lyu, K. Pollard, X. Zhang, A. T. Larsson, E. Conniff, N. Llosa, D. K. Wood, D. A. Largaespada, S. E. Moody, S. J. Gosline, A. C. Hirbe, C. A. Pratilas

This study shows that combining SHP2 inhibitor TNO155 with CDK4/6 inhibitor enhances anti-tumor activity in MPNST by restoring RB function and overcoming resistance.

bioRxiv · Feb 2, 2023Cancer Biology

Decomprolute: A benchmarking platform designed for multiomics-based tumor deconvolution

S. Feng, A. P. Calinawan, P. Pugliese, P. Wang, M. Ceccarelli, F. Petralia, S. J. Gosline

Decomprolute benchmarks multi-omic tumor deconvolution algorithms using proteogenomic data from CPTAC to improve reproducibility and reusability.

bioRxiv · Jan 5, 2023Cancer Biology

Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology

H. Bhatia^, A. T. Larsson^, A. Calizo^, K. Pollard, X. Zhang, E. Conniff, J. F. Tibbitts, S. H. Osum, K. B. Williams, A. L. Crampton, T. Jubenville, D. Schefer, K. Yang, Y. Lyu, J. Bade, , A. C. Hirbe

The paper develops an ex vivo 3D microtissue model of MPNST that captures genomic diversity and predicts in vivo drug response.

bioRxiv · Apr 29, 2022 · PreprintCancer Biology

A clinically and genomically annotated nerve sheath tumor biospecimen repository.

K. Pollard, J. Banerjee, X. Doan, J. Wang, X. Guo, R. J. Allaway, S. Langmead, B. Slobogean, C. Meyer, D. Loeb, C. Morris, A. Belzberg, J. O. Blakeley, F. Rodriguez, J. Guinney, , C. A. Pratilas

The paper establishes a clinically and genomically annotated nerve sheath tumor biospecimen repository to support research on NF1-related tumors.

bioRxiv · Dec 19, 2019Cancer Biology

Probing the chemical-biological relationship space with the Drug Target Explorer

R. Allaway, S. La Rosa, J. Guinney, S. J. Gosline

The paper introduces a web tool to explore chemical-biological interactions, enabling users to query compounds, visualize networks, and compare with HTS data for drug development.

bioRxiv · May 3, 2018Pharmacology & Toxicology