Florent Chuffart

The paper investigates chromatin state reorganization during leg regeneration in pancrustaceans, finding a conserved sequence of chromatin resetting and pioneer factor activation across species.

This study shows ATAD2 regulates chromatin-bound histone chaperone turnover, affecting H3.3 localization and gene transcription during spermatogenesis.

This study identifies KDM7B as a demethylase that regulates RNF113A, affecting DNA repair and chemoresistance in small cell lung cancer.

This paper benchmarks deconvolution algorithms for multi-omic data, identifying their strengths and limitations across different conditions and data types.

The paper identifies 154 genes downregulated via DNMT3B-driven hypermethylation in aggressive breast cancer, including GATA3, which is inactivated through either mutations or hypermethylation, both linked to poor prognosis.

This study shows that NME1/2 regulate liver response to high-fat diet by repressing de novo lipogenesis and activating protective gene expression through histone acetylation.

DECONbench benchmarks deconvolution methods for quantifying tumor cell-type heterogeneity by providing datasets, tools, and performance evaluation.

This study identifies 344 differentially methylated regions in placental DNA linked to maternal smoking, including reversible and persistent changes in former smokers.

The paper uses dynamic modeling of gene networks to interpret natural DNA variants by personalizing model parameters based on genotype, revealing how variants affect molecular regulation in yeast.

This paper introduces a method to detect genetic variants with probabilistic effects on cellular traits using single-cell data, showing improved detection of linkages missed by classical genetic mapping.