Scientific ReportsGeneticsPeer-reviewed journal article
A defined diet for pre-adult Drosophila melanogaster
Felipe MartelliiD, Annelise QuigiD, Sarah MeleiD, Jiayi LiniD, Tahlia L. FultoniD, Mia WansbroughiD, Christopher K. BarlowiD, Ralf B. SchittenhelmiD, Travis K. JohnsoniD, Matthew D. W. PiperiD
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- top 10%
Abstract
Drosophila melanogaster is unique among animal models because it has a fully defined synthetic diet available to study nutrient-gene interactions. However, use of this diet is limited to adult studies due to impaired larval development and survival. Here, we provide an adjusted formula that improves larval growth, development rate, and rescues survival. We demonstrate its use for exploring pre-adult diet compositions of therapeutic potential in a model of an inherited metabolic disorder.
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