Antimicrobial Agents and ChemotherapyGeneticsPeer-reviewed journal article
A single locus determines praziquantel response in Schistosoma mansoni
Frédéric D. ChevalieriD, Winka Le ClecʼhiD, Matthew BerrimaniD, Timothy J. C. AndersoniD
Abstract
We previously performed a genome-wide association study (GWAS) to identify the genetic basis of praziquantel (PZQ) response in schistosomes, identifying two quantitative trait loci (QTL) situated on chromosome 2 and chromosome 3. We reanalyzed this GWAS using the latest (v10) genome assembly showing that a single locus on chromosome 3, rather than two independent loci, determines drug response. These results reveal that praziquantel response is monogenic and demonstrates the importance of high-quality genomic information.
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