Duncan Berger

TRPtracker: a community database for monitoring praziquantel sensitivity at TRPMPZQ variants

TRPtracker aggregates TRPMPZQ variants and their PZQ sensitivity data to monitor resistance and support schistosomiasis control strategies.

Chromosomal genome assembly resolves drug resistance loci in the parasitic nematode Teladorsagia circumcincta

The paper generates a chromosome-scale genome assembly for Teladorsagia circumcincta and identifies genetic loci associated with drug resistance to improve anthelmintic resistance diagnostics.

Extensive transmission and variation in a functional receptor for praziquantel resistance in endemic Schistosoma mansoni

The paper uses population genomics and functional genetics to identify praziquantel resistance variants in Schistosoma mansoni.

Development of the Pneumococcal Genome Library, a core genome multilocus sequence typing scheme, and a taxonomic life identification number barcoding system to investigate and define pneumococcal population structure

The paper develops a genomic resource and clustering methods for pneumococcal population analysis using a large curated dataset of genomes.

Genome-wide analysis of Schistosoma mansoni reveals population structure and praziquantel drug selection pressure within Ugandan hot-spot communities

The paper analyzes whole-genome sequences of Schistosoma mansoni from Ugandan fishing communities to assess population structure and genetic changes associated with praziquantel treatment.

Assembled chromosomes of the blood fluke Schistosoma mansoni provide insight into the evolution of its ZW sex-determination system

The paper assembles the chromosomes of Schistosoma mansoni, revealing insights into the evolution of its ZW sex-determination system through gene annotation and synteny analysis.

Evaluation of DNA extraction methods on individual helminth egg and larval stages for whole genome sequencing

The paper evaluates DNA extraction methods for whole genome sequencing of individual helminth eggs and larvae, showing successful sequencing for six of eight species tested.

Improving the annotation of the Heterorhabditis bacteriophora genome

The paper reanalyzes the H. bacteriophora genome to determine if its unique features are biological or methodological, finding that methodological issues likely caused the initial annotation's uniqueness.