Winka Le Clecʼh

Pooled amplicon sequencing for characterizing mutations in the praziquantel molecular target TRPMPZQ in schistosome populations from Western Kenya

This study analyzes mutations in the Praziquantel target gene Sm.TRPMPZQ in schistosome populations from Western Kenya to assess their role in drug resistance.

Direct measurement of in vitro response to Praziquantel in Schistosoma mansoni populations from Western Kenya

The paper directly assays PZQ response in S. mansoni worms from Western Kenya and finds no evidence of PZQ resistance.

TRPtracker: a community database for monitoring praziquantel sensitivity at TRPMPZQ variants

TRPtracker aggregates TRPMPZQ variants and their PZQ sensitivity data to monitor resistance and support schistosomiasis control strategies.

Limited Impact of Schistosome Infection on Biomphalaria glabrata Snail Microbiomes

This study investigates how Schistosoma mansoni infection affects the microbiomes of Biomphalaria glabrata snails, finding limited changes in composition and no effect on bacterial density.

Abundant genetic variation is retained in many laboratory schistosome populations

This study finds that laboratory Schistosoma mansoni populations retain abundant genetic variation, with implications for drug resistance studies and GWAS.

Organ-Specific Microbiomes of Biomphalaria Snails

The paper investigates organ-specific microbiomes in Biomphalaria snails and finds they are less diverse than hemolymph microbiomes but cluster by physiological function.

Transcriptional phenotype of the anti-parasitic benzodiazepine meclonazepam on the blood fluke Schistosoma mansoni

This study investigates the transcriptional effects of meclonazepam on Schistosoma mansoni, showing it causes tegument damage and apoptosis, with gene expression patterns similar to but distinct from praziquantel.

Rapid phenotypic and genotypic change in a laboratory schistosome population

The paper detects recent contamination in a laboratory Schistosoma mansoni population and shows how genetic drift causes divergence in parasite populations over time.

A single locus determines praziquantel response in Schistosoma mansoni

The paper reanalyzes a GWAS to show that a single locus on chromosome 3 determines praziquantel response in Schistosoma mansoni, rather than two loci.

Prospecting for zoonotic pathogens using targeted DNA enrichment

The paper develops a targeted DNA enrichment method using RNA probes to identify zoonotic pathogens in museum-archived tissues, demonstrating its effectiveness in detecting bacterial species.

Genetic analysis of praziquantel response in schistosome parasites implicates a Transient Receptor Potential channel

The paper identifies a transient receptor potential channel (Sm.TRPMPZQ) as the genetic basis for variation in praziquantel response in Schistosoma mansoni.

Genetic architecture of transmission stage production and virulence in schistosome parasites

This study identifies five QTLs associated with cercarial production in Schistosoma mansoni using linkage analysis, explaining 28.56% of phenotypic variation.