Frédéric D. Chevalier

This study analyzes mutations in the Praziquantel target gene Sm.TRPMPZQ in schistosome populations from Western Kenya to assess their role in drug resistance.

The paper directly assays PZQ response in S. mansoni worms from Western Kenya and finds no evidence of PZQ resistance.

TRPtracker aggregates TRPMPZQ variants and their PZQ sensitivity data to monitor resistance and support schistosomiasis control strategies.

This study investigates how Schistosoma mansoni infection affects the microbiomes of Biomphalaria glabrata snails, finding limited changes in composition and no effect on bacterial density.

This study finds that laboratory Schistosoma mansoni populations retain abundant genetic variation, with implications for drug resistance studies and GWAS.

The paper investigates organ-specific microbiomes in Biomphalaria snails and finds they are less diverse than hemolymph microbiomes but cluster by physiological function.

This study investigates the transcriptional effects of meclonazepam on Schistosoma mansoni, showing it causes tegument damage and apoptosis, with gene expression patterns similar to but distinct from praziquantel.

The paper detects recent contamination in a laboratory Schistosoma mansoni population and shows how genetic drift causes divergence in parasite populations over time.

This study investigates how parasite and host genetics influence immunopathology and infection outcomes in Schistosoma mansoni infections in mice.

The paper reanalyzes a GWAS to show that a single locus on chromosome 3 determines praziquantel response in Schistosoma mansoni, rather than two loci.

The paper identifies a transient receptor potential channel (Sm.TRPMPZQ) as the genetic basis for variation in praziquantel response in Schistosoma mansoni.

This study identifies five QTLs associated with cercarial production in Schistosoma mansoni using linkage analysis, explaining 28.56% of phenotypic variation.