This study uses immunolocalization and single-cell RNAseq to show TRPMPZQ expression in excitable cells and sensory structures across Schistosoma mansoni life stages, with reduced expression in PZQ-resistant strains.

bioRxiv · Oct 17, 2026 · PreprintMicrobiology

TRPtracker: a community database for monitoring praziquantel sensitivity at TRPMPZQ variants

Claudia M. Rohr, Sang-Kyu Park, Kelsilandia Aguiar-Martins, Timothy J.C. Anderson, Duncan Berger, Matthew Berriman, Sarah K. Buddenborg, Amaya L. Bustinduy, Frédéric D. Chevalier, James Anthony Cotton, Thomas Crellen, Stephen R. Doyle, Aidan Mark Emery, Julien Kincaid-Smith, Safari Kinung'hi, , Jonathan S. Marchant

TRPtracker aggregates TRPMPZQ variants and their PZQ sensitivity data to monitor resistance and support schistosomiasis control strategies.

International Journal for Parasitology Drugs and Drug Resistance · Mar 18, 2026Peer-reviewedMicrobiology

Clonazepam activates the transient receptor potential melastatin 8 (TRPM8) ion channel

Logan Elkin, Evgeny G. Chulkov, Jonathan David Enders, Anthony D. Menzel, Sang-Kyu Park, Cheryl L. Stucky, Jonathan S. Marchant

The paper shows clonazepam activates TRPM8 ion channels, which may explain its efficacy in treating burning mouth disorder.

bioRxiv · Jan 22, 2026 · PreprintNeuroscience

Extensive transmission and variation in a functional receptor for praziquantel resistance in endemic Schistosoma mansoni

Duncan Berger, Sang-Kyu Park, Thomas Crellen, John Vianney Tushabe, Narcis B. Kabatereine, James Anthony Cotton, Richard E. Sanya, Alison Elliot, Edridah Muheki Tukahebwa, Moses Adriko, Claire J. Standley, Anouk Gouvras, Safari Kinung’hi, Helmut Haas, Muriel Rabone, , Joanne P. Webster

The paper uses population genomics and functional genetics to identify praziquantel resistance variants in Schistosoma mansoni.

bioRxiv · Aug 29, 2024 · PreprintGenomics