Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit
Megumi Kishimoto‐Urata, Shinji UrataiD, Ryoji KagoyaiD, Fumiaki ImamuraiD, Shin NagayamaiD, Rachel A. ReynaiD, Junki MaruyamaiD, Tatsuya YamasobaiD, Kenji KondoiD, Sanae Hasegawa‐IshiiiD, Slobodan PaessleriD
Abstract
The impact of SARS-CoV-2 on the olfactory pathway was studied over several time points using Syrian golden hamsters. We found an incomplete recovery of the olfactory sensory neurons, prolonged activation of glial cells in the olfactory bulb, and a decrease in the density of dendritic spines within the hippocampus. These data may be useful for elucidating the mechanism underlying long-lasting olfactory dysfunction and cognitive impairment as a post-acute COVID-19 syndrome.
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