Pierre‐Marie Lledo

Olfactory learning potentiates long-range cortical GABAergic inputs onto adult-born neurons.

This study shows that olfactory learning enhances cortical GABAergic inputs onto adult-born neurons in the olfactory bulb, influencing olfactory behavior.

Cerebral Venous Blood Flow Regulates Brain Fluid Clearance via Dural Lymphatics

This study shows that dural venous stenoses impair lymphatic drainage and brain fluid clearance, and that restoring venous flow can improve clearance in a mouse model.

Dissecting the contribution of vagal subcircuits in sepsis-induced brain dysfunctions.

This study investigates the role of vagal subcircuits in sepsis-induced brain dysfunction using rodent models and manipulates vagus nerve activity to assess its impact on inflammation and behaviour.

Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants

The paper investigates whether neuroinvasion and anosmia are independent outcomes of SARS-CoV-2 infection by analyzing clinical, olfactory, and neuroinflammatory responses in infected golden hamsters.

Basolateral amygdala circuits supporting negative emotional bias in a mouse model for depression

The paper shows that depressive-like states in mice exhibit negative emotional bias, linked to altered basolateral amygdala (BLA) circuits and mitigated by antidepressants or chemogenetic interventions.

Long-range GABAergic projections contribute to cortical feedback control of sensory processing.

The paper identifies long-range GABAergic inhibitory feedback from cortical areas to the olfactory bulb, showing its role in modulating sensory processing and odor discrimination.

Age-associated gut microbiota impairs hippocampus-dependent memory in a vagus-dependent manner

This study shows that age-related gut microbiota impair hippocampus-dependent memory via a vagus nerve-dependent mechanism, and suggests pharmacogenetic vagus stimulation as a potential therapeutic strategy.

COVID-19-associated olfactory dysfunction reveals SARS-CoV-2 neuroinvasion and persistence in the olfactory system

This study investigates SARS-CoV-2 infection in the olfactory system, showing viral persistence and inflammation linked to prolonged loss of smell in COVID-19 patients.

Interneuron activity-structural plasticity association is driven by context-dependent sensory experience

The paper shows that odor experience correlates individual GC activity with spine stability, driven by MC activity, and models how this supports odor discrimination and memory.

The impact of gut microbiota on depressive-like behaviors and adult hippocampal neurogenesis requires the endocannabinoid system

This study shows that gut microbiota changes induced by chronic stress affect depressive-like behaviors and adult hippocampal neurogenesis through the endocannabinoid system in mice.

Gut microbiota requires vagus nerve integrity to promote depression

The paper shows that stress alters gut microbiota, which can induce depression and reduce neurogenesis, but this effect is blocked by vagus nerve disruption.