Guilherme Dias de Melo

Ivermectin's protection in SARS-CoV-2-infected hamsters depended partly on both α7 nicotinic and P2X4 receptors; in co-cultures its effects were α7nAChR-independent, and P2X4 blockade prevented CXCL10 induction at 48 hpi.

This study shows SARS-CoV-2 ORF9b uses TOMM70 to avoid proteasomal degradation, reduces inflammation, and is not essential for viral replication or lung pathology.

This study evaluates monoclonal antibodies RVC20 and RVC58 for treating symptomatic rabies in mice, showing that intravenous and intramuscular administration can clear viral infection and improve survival, with RVC58 achieving 80% survival.

RNA2seg is a cell segmentation model for spatial transcriptomics trained on MERFISH and CosMx data, showing superior performance in zero-shot and few-shot settings.

This study shows that SARS-CoV-2 infects and persists in hamster brainstem, causing neurodegenerative and immunometabolic changes linked to neuropsychiatric and cognitive symptoms.

This study shows that the SARS-CoV-2 E protein's PDZ-binding motif enhances virulence by disrupting epithelial barriers and inflammation, but not neuroinvasion.

The paper investigates whether neuroinvasion and anosmia are independent outcomes of SARS-CoV-2 infection by analyzing clinical, olfactory, and neuroinflammatory responses in infected golden hamsters.

This study investigates SARS-CoV-2 infection in the olfactory system, showing viral persistence and inflammation linked to prolonged loss of smell in COVID-19 patients.