bioRxivNeurosciencePreprint
Uncovering network mechanism underlying thalamic deep brain stimulation
Yupeng TianiD, Edward M. BelloiD, David CromptoniD, Zoe Paraskevopoulos, Suneil Kumar KaliaiD, Mojgan HodaieiD, Andrés M. LozanoiD, William D. HutchisoniD, Matthew D. JohnsoniD, Miloš R. PopovićiD, Luka MiloseviciD, Milad LankaranyiD
Abstract
Thalamic ventral intermediate nucleus (Vim) is the primary surgical target of deep brain stimulation (DBS) for reducing symptoms of essential tremor. High-frequency Vim-DBS ([≥]100Hz) has been clinically effective, generating two experimentally-observed features in Vim spiking activity: 1) a large transient excitatory response (lasting View larger version (23K): org.highwire.dtl.DTLVardef@1e78cbcorg.highwire.dtl.DTLVardef@c8bde1org.highwire.dtl.DTLVardef@12a3bb3org.highwire.dtl.DTLVardef@1b5a0dd_HPS_FORMAT_FIGEXP M_FIG C_FIG
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