Xue Han

The paper investigates how subthreshold membrane depolarization influences intracellular calcium dynamics in awake mice, showing strong coupling during prolonged depolarization and weaker coupling during isolated spikes.

This study shows striatal cholinergic interneurons signal aversion and drive avoidance by responding more strongly to negative cues during learning.

The paper investigates how excitation and inhibition shape theta-gamma coupling in the medial entorhinal cortex using experimental and computational methods, revealing distinct cell-type contributions to oscillatory activity.

This study shows that deep brain stimulation reduces pathological STN dynamics and rescues gait deficits in dopamine-depleted Parkinson's mice.

This paper introduces GRID, a high-throughput image analysis method using dispersion indices to quantify subcellular structure dynamics and spatial distributions across diverse biological contexts.

The paper analyzes the relative phase of membrane potential theta oscillations between hippocampal neurons during a virtual spatial task, revealing spatially coded phase shifts independent of spiking activity.

This paper demonstrates that modified self-amplifying RNA (saRNA) enables long-lasting protein expression in mouse and human brain tissues.

This study shows that transcranial ultrasound stimulation modulates neuronal membrane potentials in awake mice, with rapid depolarizations and entrainment effects.

This paper investigates how high frequency electrical stimulation modulates fast spiking interneurons in different brain regions, finding region-specific entrainment and bidirectional effects on temporal processing.

The paper demonstrates prolonged single-neuron voltage imaging in behaving mice using ElectraOFF, revealing plasticity changes during neuromodulation.

The paper presents a network model of cortical circuits that explains how parvalbumin neurons enhance neural discriminability of dynamic stimuli through distinct temporal coding mechanisms.

The paper shows that 10 Hz sensory stimulation enhances delta rhythmicity of stepping movement and strengthens coupling between striatal networks and movement in mice.

The paper shows that different ultrasound pulse repetition frequencies selectively activate distinct neuron populations in the mouse motor cortex, independent of cell type.

This paper introduces a microscope combining targeted illumination and confocal gating to improve voltage imaging in dense tissues, enhancing signal-to-noise ratio and reducing crosstalk.

This paper introduces a photothrombotic stroke model in mice that reproduces human epilepsy electrographic biomarkers, showing increased spike ripples and delta power in the stroke hemisphere.

The paper investigates how auditory cortex populations code competing sounds using information theory, finding that a diverse labeled line code outperforms summed population codes and achieves near-noiseless information transmission.

The paper investigates the role of parvalbumin neurons in cortical temporal coding during complex scene analysis, finding that their suppression degrades dynamic sound discrimination in a cocktail party-like setting.

The paper shows that parvalbumin interneurons synchronize their membrane voltage with hippocampal theta rhythms, organizing spike timing and network dynamics during locomotion.

This study investigates how the ASD risk gene NEXMIF affects hippocampal CA1 network dynamics in mice, finding increased synchronization and exaggerated movement responses without changes in individual neuron excitability.

The paper shows that single and complex spikes in hippocampal neurons encode frequency-specific information during spatial navigation, with distinct roles for theta and gamma rhythms.

This study shows that deep brain stimulation (DBS) causes membrane depolarization in hippocampal neurons, impairing their ability to process inputs and creating an information lesion.

The paper uses calcium imaging in mice to show that distinct CA1 neuronal populations and connectivity patterns underlie trace conditioning and extinction learning.

This paper demonstrates targeted illumination with SomArchon to enable large-scale voltage imaging in the brain, improving signal contrast and reducing background contamination.

The paper investigates how excitatory and inhibitory neurons in the prefrontal cortex of mice respond during a sensory discrimination task and their relationship with LFP oscillations.

This paper introduces a novel miniaturized mesoscope for cellular-resolution imaging of neural activity in freely behaving mice, enabling comprehensive visualization across brain regions.

The paper shows that increased alpha/beta oscillations and coherence between auditory and prefrontal cortices during extinction learning correlate with improved behavioral performance in mice.

The paper develops cell body-targeted calcium indicators to improve signal fidelity in one-photon imaging of neural activity in live mice and zebrafish.

This paper introduces a miniaturized Fiber-Optoacoustic Converter for high spatial precision neural stimulation in mice, achieving submillimeter resolution in vivo.

The paper introduces a new genetically encoded voltage indicator, SomArchon, enabling high-speed, sensitive neural activity imaging in awake mice across multiple brain regions.

The paper introduces a Teensy microcontroller-based interface for precise camera control during behavioral experiments, demonstrating its flexibility and temporal precision in two experimental setups.