Differential activity patterns in the upper and lower blade of the dentate gyrus

Abstract

The dentate gyrus is considered the first stage in the trisynaptic circuit of the hippocampus. Granule cells of the dentate gyrus fire very sparsely with a low probability of overlapping patterns of active neurons. This characteristic supports the most prevalent view of the dentate gyrus function as that of a pattern separator: to generate dissimilar neuronal representations from overlapping input states that represent similar but not identical environments. However, there are two distinct granule cell blades that have been shown to have different activity patterns: the upper blade and the lower blade. These may support different purposes, but their differential function is not well understood. Here we have recorded calcium imaging data from both the upper and the lower blade of the dentate gyrus from two mice (the upper blade from one, the lower blade from the other), while they perform a simple decision-making task. We found that only the lower blade encodes subjective emotional response while the upper blade preferentially encodes the actual response. Importantly, we found that correlations between cells carried more information about these two behavioural variables than individual firings, suggesting that neuron correlations encode here important information above and beyond individual unit activity.