Author

Shintaro Otsuka

Northwestern UniversityORCID 0000-0002-1890-9971Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Anis ContractoriD· 4 shared Jian XuiD· 2 shared K. SuzukiiD· 2 shared Keiko MatsudaiD· 2 shared Michisuke YuzakiiD· 2 shared Alexander E. DityateviD· 1 shared Alexandru Radu AricescuiD· 1 shared Amber J. ClaytoniD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersNeuroscience

Anis ContractorORCID

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Author profile →

5 papers

Recent·Most cited

Subregional activity in the dentate gyrus is amplified during elevated cognitive demands

Charlotte Castillon, Shintaro Otsuka, John N. Armstrong, Anis Contractor

This study shows that increased cognitive demand in mice enhances spatial activity in the suprapyramidal blade of the dentate gyrus, with specific roles for mature and adult-born granule cells.

eLife · May 14, 2026Peer-reviewedNeuroscience

Autism associated mutation in Cacna1d causes perseverative behavioral phenotype in mice

Shintaro Otsuka, Jian Xu, Anis Contractor

This study shows that an autism-linked mutation in Cacna1d causes perseverative behaviors in mice without affecting anxiety or locomotion.

bioRxiv · Jan 14, 2026 · PreprintNeuroscience

Operant House: A Versatile Open-Source Platform for Automated Operant Conditioning Testing of Mice in Home Cages

Shintaro Otsuka, Yuriko Nakamura, Aya Ito, K. Suzuki, Ayako Wendy Ishikawa, Keiko Matsuda, Shigetomo Suyama, Anis Contractor, Michisuke Yuzaki

Operant House is a low-cost, automated platform for operant conditioning testing in mice, revealing early working memory deficits in a Alzheimer's disease model.

bioRxiv · Jan 24, 2025 · PreprintNeuroscience

Ca2+-dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapses

Shenyu Zhai, Shintaro Otsuka, Jian Xu, Vernon R. J. Clarke, Tatiana Tkatch, David L. Wokosin, Zhong Xie, Asami Tanimura, Hitesh K. Agarwal, Graham C. R. Ellis‐Davies, Anis Contractor, Dalton James Surmeier

The paper identifies Ca2+-dependent phosphodiesterase 1 (PDE1) as a regulator of NO-induced long-term depression (NO-LTD) in striatal spiny projection neurons, linking it to synaptic plasticity and Parkinson's disease.

Cell Reports · Jul 26, 2024Peer-reviewedNeuroscience

A synthetic synaptic organizer protein restores glutamatergic neuronal circuits

K. Suzuki, Jonathan Elegheert, Inseon Song, Hiroyuki Sasakura, Oleg Senkov, Keiko Matsuda, Wataru Kakegawa, Amber J. Clayton, Veronica T.-C. Chang, Maura Ferrer-Ferrer, Eriko Miura, Rahul Kaushik, Masashi Ikeno, Yuki Morioka, Yuka Takeuchi, , Michisuke Yuzaki

The paper designs and characterizes CPTX, a synthetic protein that restores synaptic function and behavior in mouse models of neurological diseases.

Science · Aug 28, 2020Peer-reviewedNeuroscience