J. H. M. Prehn

This study identifies two molecular phenotypes, ADA and N-ADA, associated with temozolomide resistance in glioblastoma cells through bulk and single-cell RNA sequencing.

This paper identifies four microbial subtypes in colorectal cancer tumours and adjacent mucosa, linking them to clinical and molecular features and demonstrating prognostic value.

This study identifies Bcl-xL as a mediator of resistance to KRASG12C inhibitors in colorectal cancer and shows that combining Bcl-xL inhibition with KRASG12C inhibition enhances apoptosis and reduces tumor growth.

This study uses multiplexed imaging and single-cell analysis to classify immune cells in stage III colorectal cancer patients, finding that multi-marker Treg classification better predicts survival than single markers.

The paper develops a method to profile N-respirasomes at single-cell resolution and identifies CHCHD3's role in regulating them, revealing mitochondrial bioenergetic abnormalities.

This study identifies TRAIL as a promoter of entosis in colorectal cancer cells and links CICs to poor patient prognosis.