Acute Ischemic Stroke Management

This study compares gene expression profiles of stroke-affected tissue across species and time points to identify heterogeneity in stroke-related pathways and gene expression changes.

This study shows that leptomeningeal collaterals regulate reperfusion in ischemic stroke, with poor collaterals leading to hemorrhage and poor outcomes.

This paper presents a high-resolution micro-CT imaging approach for detailed infarct characterization and automatic segmentation in mouse stroke models.

The paper identifies key genes and pathways associated with stroke types and subtypes using computational methods and finds a prognostic gene signature for stroke risk prediction.

This study identifies sex-specific lesion patterns in acute ischemic stroke that correlate with stroke severity, highlighting differences in lesion distribution between men and women.

This study shows that peripheral electrical stimulation can increase cerebral collateral blood flow in mice after stroke, but only if applied within the first hour.

The paper identifies dynamic capillary flow stalls in mice after stroke reperfusion, mediated by neutrophils, which impair circulation and contribute to penumbral injury.

This study characterizes acute tissue and functional deficits in a pig model of ischemic stroke to identify treatment targets and inform therapeutic development.

The paper identifies four new neuroprotective loci modulating cerebral infarct volume in mice by comparing wild-derived strains and finds candidate genes associated with these loci.

The paper examines the role of inflammation markers and blood-brain barrier damage in predicting short-term post-stroke outcomes.

This paper develops a logistic regression model to diagnose mild stroke/TIA using clinical symptoms, achieving better performance than the ABCD2 score in a validation set.