Kıvılcım Kılıç

This study shows anti-Aβ immunotherapy triggers rapid immune-vascular interactions in the leptomeningeal interface, leading to peripheral immune cell adhesion and potentially contributing to ARIA.

This paper introduces blood-mediated optoacoustic stimulation (BOAS) for precise brain cortex stimulation, showing it can trigger neuronal activity comparable to natural visual stimulation and is more efficient than photothermal methods.

This study shows that visual gamma stimulation increases low-frequency blood flow oscillations in multiple cortical regions of mice, with effects lasting beyond 24 hours.

This study identifies distinct Ca2+ signaling profiles in leptomeningeal fibroblast subgroups in awake mice under health and inflammation conditions.

The paper shows that hemodynamic responses in the cortex are influenced by neuromodulators like norepinephrine, with distinct impulse response functions for different neuromodulatory signals.

The paper describes a widefield in vivo imaging system for mesoscopic brain imaging, capable of capturing fluorescent and reflectance signals, and demonstrates its use in awake mice.

The paper shows visual stimulation causes retinotopic acetylcholine release in the mouse visual cortex, indicating organized cholinergic signaling.

The paper uses two-photon calcium imaging and surface electrophysiology to show that only a small fraction of layer 2 neurons follow surface MUA, suggesting MUA may primarily reflect axonal inputs.

The paper measures oxygen consumption across cortical layers in awake mice and finds a decrease in baseline CMRO2 from layer I to IV, accompanied by increased tissue oxygenation.

The paper identifies three distinct classes of cortical activity using high-density microelectrodes, showing they are modulated by stimuli and present across species.

This paper introduces a novel miniaturized mesoscope for cellular-resolution imaging of neural activity in freely behaving mice, enabling comprehensive visualization across brain regions.

This study shows that mild traumatic brain injury rapidly disrupts cortical microcirculation, causing severe reductions in cerebral blood flow and vascular dysfunction.

The paper identifies dynamic capillary flow stalls in mice after stroke reperfusion, mediated by neutrophils, which impair circulation and contribute to penumbral injury.

The paper measures capillary flow and oxygenation in cortical layers of awake mice, finding homogenization of oxygen delivery and increased extraction in layer IV.