Acute Ischemic Stroke Management

Knockdown of endothelial Serpine1 improves stroke recovery by attenuating peri-infarct blood flow and blood brain barrier disruption

This study shows that reducing Serpine1 in endothelial cells after stroke improves recovery by reducing blood flow and preventing blood-brain barrier damage.

Early Prediction of Ischaemic Stroke Outcomes: A Novel Computational Approach

This paper introduces a computational pipeline to predict brain swelling after stroke using a mathematical model and deep neural network, achieving an AUC of 0.7 in predicting 3-month outcomes.

Hemodynamic and electrophysiological progression of the Rose Bengal photothrombotic stroke model in mice: vasoactive properties of Rose Bengal, tissue heating, wavelength optimization, and sex differences in lesion volume

This study characterizes the hemodynamic and electrophysiological effects of the Rose Bengal photothrombotic stroke model in mice, identifying confounding factors and sex differences in stroke outcomes.

Tryptophan metabolites as biomarkers to predict the severity and prognosis of acute ischemic stroke patients

This study identifies tryptophan metabolites as biomarkers for predicting 3-month functional outcomes in acute ischemic stroke patients.

Head down tilt 15° increases cerebral perfusion before recanalization in acute ischemic stroke: a pre-clinical MRI study.

This study shows that head down tilt 15° increases cerebral perfusion and reduces infarct growth in a rat model of acute ischemic stroke before recanalization.

Intra-arterial Deoxyribonuclease therapy improves stroke outcomes in aged mice

This study shows that intra-arterial DNase therapy improves stroke outcomes in aged mice by enhancing reperfusion and reducing NETs.

Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents

This study reviews preclinical evidence on CCR5 antagonists' effects on stroke outcomes and recovery, finding reduced infarct volume and improved behavioral outcomes, but highlighting significant bias and knowledge gaps.

Harnessing micrometer-scale tPA beads for high plasmin flux and accelerated fibrinolysis

This paper develops micrometer-scale tPA beads that enhance plasmin generation and fibrinolysis, achieving rapid thrombus removal in a mouse stroke model with lower doses than standard tPA.

MicroRNAs and mRNA Regulatory Network of Parenchymal Hematoma after Endovascular Mechanical Reperfusion for Acute Ischemic Stroke in Rat

The paper identifies microRNA and mRNA regulatory networks associated with parenchymal hematoma after mechanical reperfusion in a rat stroke model.

Inhibition of nitric oxide synthase transforms carotid occlusion-mediated benign oligemia into de novo large cerebral infarction

The paper investigates how NOS inhibition transforms benign oligemia into large cerebral infarction in mice and links SDMA levels to ischemic stroke risk in humans.

Development of endothelial-targeted CD39 as a therapy for ischaemic stroke

This paper develops an endothelial-targeted CD39 therapy for ischaemic stroke, showing reduced infarct size and improved BBB integrity when administered 3 hours post-ischaemia.

Comprehensive Assessment of Ischemic Stroke in Nonhuman Primates: Neuroimaging, Behavioral, and Serum Proteomic Analysis

This study assesses ischemic stroke in nonhuman primates using neuroimaging, behavioral analysis, and serum proteomics to identify biomarkers and understand stroke pathophysiology.

LOX-1 and MMP-9 inhibition attenuates the detrimental effects of delayed rt-PA therapy and improves outcomes after acute ischemic stroke

This study shows that inhibiting LOX-1 and MMP-9 with drugs improves outcomes after delayed rt-PA treatment in stroke by reducing hemorrhage and edema.

APOL1 Risk Variants Associate with the Prevalence of Stroke in African American Current and Past Smokers

The paper investigates the interaction between APOL1 risk variants and smoking in African Americans, finding that carriers of these variants have increased stroke risk among smokers.

Prediction of Stroke Outcome in Mice Based on Non-Invasive MRI and Behavioral Testing

This paper predicts stroke outcomes in mice using MRI and behavioral data, finding that lesion volume and topology are key predictors of subacute and residual deficits.

Spreading depolarization causes reperfusion failure after cerebral ischemia

This study shows that spreading depolarization during ischemia predicts reperfusion failure and poor outcomes, and inhibiting it improves reperfusion.

A cross-species approach using an in vivo evaluation platform in mice demonstrates that sequence variation in the human RABEP2 gene modulates ischemic stroke outcomes

The impacts of anesthetic regimens on the middle cerebral artery occlusion outcomes in male rats

This study compares the effects of different anesthetic regimens on MCAO outcomes in male rats, finding that subcutaneous ketamine-xylazine has the lowest mortality rate.

Feature-based Quality Assessment of Middle Cerebral Artery Occlusion Using 18F-fluorodeoxyglucose Positron Emission Tomography

The paper introduces a feature-based method using FDG PET images and SVM to assess MCAO quality in rats, achieving high accuracy in classification.

Depth-targeted intracortical microstroke by two-photon photothrombosis in rodent brain

The paper describes a two-photon photothrombosis protocol to induce depth-targeted single vessel thrombosis in rodent brains with high success rate.

Modelling the effects of cerebral microthrombi on tissue oxygenation and cell death

This paper models how cerebral microthrombi affect tissue oxygenation and cell death using computational simulations and a hypoxia-based cell death model.

A neuroprotective locus modulates ischemic stroke infarction independent of collateral vessel anatomy

This study identifies a genetic locus that reduces infarct size after ischemic stroke in mice, independent of collateral vessel anatomy, by uncovering the neuroprotective role of Msr1.

Modelling the impact of clot fragmentation on the microcirculation after thrombectomy

The paper develops an in-silico model to simulate micro-emboli effects on brain microcirculation after thrombectomy, finding capillary beds are more susceptible to occlusion than arterioles.

Rich-Club organization: an important determinant of functional outcome after acute ischemic stroke

This study shows that the number of rich-club brain regions affected by stroke predicts worse functional outcomes better than traditional markers like lesion volume and age.

Comparison of classification methods for tissue outcome after ischemic stroke

The paper compares five classification methods for identifying high-risk infarction tissue in ischemic stroke using MRI data, finding no significant difference in precision-recall performance.

Effective reserve: a latent variable to improve outcome prediction in stroke

This paper introduces effective reserve (eR), a latent variable derived from clinical and imaging data, to improve prediction of functional outcomes after acute ischemic stroke.

INCLUSION CRITERIA UPDATE OF THE INTRALUMINAL ISCHEMIC MODEL IN RAT FOR PRECLINICAL STUDIES

The study shows that combining laser Doppler with MRI techniques improves reproducibility of infarct volume in rat stroke models.

Stroke-associated pattern of gene expression previously identified by machine-learning is diagnostically robust in an independent patient population.

The paper validates a previously identified ten-gene expression pattern for stroke detection in an independent cohort, showing high sensitivity and specificity across multiple time points.