Author

Han Kyu Lee

Duke Medical CenterORCID 0000-0002-0876-7404Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 3 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Douglas A. MarchukiD· 4 shared David L. AyloriD· 3 shared Chao-Chieh Lin· 1 shared Denise Dunn· 1 shared Do Hoon Kwon· 1 shared Jen‐Tsan ChiiD· 1 shared Min-Nung HuangiD· 1 shared Samuel J. WidmayeriD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersGenetics

Douglas A. MarchukORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Targeting the ferroptosis pathway: A novel compound, AZD1390, protects the brain after ischemic stroke

Han Kyu Lee, Chao-Chieh Lin, Denise Dunn, Yubin Chen, Ssu-Yu Chen, Douglas A. Marchuk, Scott Floyd, Jen‐Tsan Chi

This study shows that ATM inhibition with AZD1390 reduces ferroptosis and neuronal death in ischemic stroke models.

bioRxiv · Feb 22, 2025 · PreprintNeuroscience

A cross-species approach using an in vivo evaluation platform in mice demonstrates that sequence variation in the human RABEP2 gene modulates ischemic stroke outcomes

Han Kyu Lee, Do Hoon Kwon, David L. Aylor, Douglas A. Marchuk

The American Journal of Human Genetics · Sep 26, 2022Peer-reviewedGenetics

A neuroprotective locus modulates ischemic stroke infarction independent of collateral vessel anatomy

Han Kyu Lee, Sarah E. Wetzel‐Strong, David L. Aylor, Douglas A. Marchuk

This study identifies a genetic locus that reduces infarct size after ischemic stroke in mice, independent of collateral vessel anatomy, by uncovering the neuroprotective role of Msr1.

Frontiers in Neuroscience · Aug 2, 2021Peer-reviewedGenetics

Identification of novel neuroprotective loci modulating ischemic stroke volume in a cross between wild-derived inbred mouse strains

Han Kyu Lee, Samuel J. Widmayer, Min-Nung Huang, David L. Aylor, Douglas A. Marchuk

The paper identifies four new neuroprotective loci modulating cerebral infarct volume in mice by comparing wild-derived strains and finds candidate genes associated with these loci.

bioRxiv · Aug 1, 2019 · PreprintGenetics